Mélanie Prague

Postdoctoral Reasearch Fellow in Biostatistics

Harvard T.H. School of Public Health



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PRIMARY KEY WORDS : Bayesian statistics; Semi-parametric statistics; Dynamical models; Mechanistic Models; Ordinary differential Equations (ODE); non linear Mixed effects models (NLME); Generalized Estimating equation (GEE); missing data; HIV; causality; optimal control theory; numerical optimization.
SECONDARY KEY WORDS : Biomarkers; Biostatistics; High-dimensional data; HIV; Immunology; Personalized medicine; Pharmacometrics; Randomization; Transcriptomic data; Trials design; Vaccine.

Since Februrary 2014, I am a postdoctoral research fellow in Harvard T.H. Chan School of Public Heath in Boston MA USA. I work within the HIV quantitative, the causality and the network working group. I am particularly interested in cluster randomized trial with missing data and interference (when subjects' outcomes depend on other subjects' covariates) using semi-parametric statistics. My main advisors and collaborators are Victor De Gruttola, Rui Wang, JP Onnela and Eric Tchetgen Tchetgen.

In December 2013 and January 2014 I was an invited researchor in the biostatistics department of the Unisersity of Oslo, Norway. I focussed on comparing different approach to evaluate the treatment effect in oberservationnal studies, in particular, Marginal Structural Models and dynamical models. My main collaborators were Odd Aalen and Jon Michael Gran.

Between 2010 and 2013, I was a PhD student at the ISPED (Institut de Santé Publique, d'Epidémiologie et de Developpement), the public health and epidemiology lab of Universite de Bordeaux. I work within the research theme Statistics in Biology, Immunology and vaccinology of the team Biostatistics. My interest was on mechanistic modeling of HIV for individual treatment adaptation. My advisor was Daniel Commenges but I also closely worked with Rodolphe Thiébaut. I defended November 15th 2014.

After a Post-Secondary Preparatory Classes ('Classes préparatoire aux grandes écoles'), I graduated in 2010 from ENSAI (National school of statistics and analysis of information), Bruz Rennes France. I also obtained this same year a Master 2 from University of Rennes 1 in Mathematics, statistics and econometry. Of note, I also gratuated from a bachelor from Rennes 2 in eEonomics in 2009.

DOWNLOAD MY CV : CV_Prague.pdf.

2016 [G-2016-1]

Harvard Rose fellowship Award
4 prices a year to offer a cross-cultural experience of research in developing country. My project concerns: "Estimation of incidence and prevalence of HIV in Botswana: pooling data from different registers to evaluate the impact of personal characteristics such as citizenship".

2015 [G-2015-2]

Statistical French Society Award
Marie-Jeanne et Laurent Duhamel price 2015. Marie-Jeanne Laurent-Duhamel award. Price given once every other year and awarding scientific quality of PhD works in Applied Statistics.

2015 [G-2015-1]

Philippe foundation (renewal) 6000$ personal grant for research travels. My project concerned: "Evaluating and targeting of HIV prevention strategies".

2014 [G-2014-1]

Philippe foundation
Non-profit organization for Franco-American exchanges (5000$ personal grant). My project concerned: "Methods for analyzing HIV clustered randomized data and cohort data with informative missingness".

2011 [G-2011-1]

Selected for summer school Sidaction Young researchers.
One week intensive class program to mix multidisciplinary early-stage researchers in order to promote collaborations in the field of HIV.

2014 - ...

Postdoctoral research fellow in Harvard T.H. School of public Health, Boston USA
“Semi-parametric estimation of treatment effect in clustered randomized trials in presence of missing data: application to HIV prevention in South Africa”
Advisor : Victor DeGruttola
Biostatistics Department.

Dec 2013 - Jan 2014

Invited researcher University of Oslo, Norway
“Comparison of propensity score based methods and dynamical methods for estimation of treatment effect in observational studies”
Advisor : Odd Aalen
Biostatistics Department .

2010 - 2013

Ph.D. in Public Health and Biostatistics “Monitoring of HIV infected patients based on dynamic models”
Advisor : Daniel Commenges
Biostatistics, École Doctorale SP2 (Political science and public health) within the University of Bordeaux.

April - August 2008

Averion International - SAS programmer, Basel Switzerland.
Internship. Phase III Clinical Trial in oncology.
Supervisor : Mikael Saulay

June - Sept 2008

INSERM U897 - Data entry operator, Bordeaux France.
Internship. I also performed basic descriptive statistics.
Supervisor : Sylvie Maurice

Education

2014

Qualification Section CNU 26

2010 - 2013

Ph.D. in Public Health and Biostatistics “Monitoring of HIV infected patients based on dynamic models”
Advisor : Daniel Commenges (daniel.commenges@isped.u-bordeaux2.fr)
Biostatistics, École Doctorale SP2 (Political science and public health) within the University of Bordeaux.

2009 - 2010

Master of Science (M.Sc.) in Statistics and Econometrics (dual curriculum)
Department of Mathematics, University of Rennes 1

2007 - 2010

Master’s Degree in Engineering in Statistics (equivalent M.Sc)
ENSAI, National School for Statistics and Information Analysis, Rennes (Bruz), France

2008 - 2009

Bachelor of Science (B.Sc.) in Economics (dual curriculum)
Department of Economics, University of Rennes 2

2005 - 2007

Post-Secondary Preparatory Classes – Lycée Montaigne, Bordeaux, France
University-level courses required in preparation for competitive exams into top universities, engineering, and graduate schools (France’s “Grandes Écoles”).
Major : Mathematics and Physics

2004 - 2005

High school diploma with high honors – Lycée V. Louis, Talence, France
Major: scientific, Specialization: Mathematics